NanoConstruct: Digital Construction of Ellipsoidal Nanoparticles & Crystal Growth

How NovaMechanics extended ASCOT to enable construction of ellipsoidal nanoparticles from any material via CIF file upload, investigation of crystal growth, and automated calculation of atomistic descriptors — democratizing computational nanomaterial design for Safe and Sustainable by Design.

Computational and Structural Biotechnology Journal • 2024
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The Challenge

Democratizing Computational Exploration of Crystal Growth

Investigating the crystal growth, stability, and properties of nanoparticles is experimentally slow, expensive, and limited to materials already synthesized. The Crystallography Open Database contains over 50,000 crystal structures, yet no computational tool existed to systematically explore their potential behavior as nanoparticles.

NanoConstruct addresses this gap by extending ASCOT's capabilities to any material and ellipsoidal geometries. Users can upload crystal structure files (CIF) from public databases, perform hypothetical element substitutions, and computationally investigate crystal growth, stability, and atomistic properties — accelerating Safe and Sustainable by Design innovation without requiring programming expertise.

50,000+
Crystal structures accessible from Crystallography Open Database
Any Material
Support for arbitrary materials via CIF file upload
Zero Code
Fully automated pipeline from CIF to descriptors

Our Approach

A generic computational workflow to explore crystal growth of any material at the nanoscale

Load CIF and visualize unit cell

Upload any material's crystallographic information file (CIF) directly from the Crystallography Open Database. The tool validates the structure and provides immediate 3D visualization of the unit cell, making it accessible to non-experts.

Optional element substitution

Perform in silico element substitutions using same-group neighbors or adjacent rows of the periodic table to explore hypothetical material variants without requiring synthesis. This enables rapid screening of structural stability and property changes.

Define NP geometry

Specify nanoparticle geometry as spherical or ellipsoidal with custom axes and rotation angles. Replicate the unit cell into a bounding box and remove atoms outside the target shape while enforcing stoichiometric correctness via iterative shell removal (4 Å surface thickness).

Energy minimization

Apply molecular dynamics energy minimization using LAMMPS with conjugate gradient method and appropriate force fields from the OpenKIM database. Reactive force fields enable bond breaking and formation at NP surfaces for realistic crystal structures.

Calculate atomistic descriptors

Automatically compute geometrical (surface area, volume, ellipsoid axes) and atomistic (potential energy, coordination numbers, common neighbour parameters, hexatic order) descriptors. Results are separated into core and shell regions for detailed analysis of crystal growth patterns.

Results at a Glance

Any Material
Universal CIF Support
Upload crystal structures from any database for computational investigation
Ellipsoidal
Custom NP Geometries
Support for spherical and ellipsoidal shapes with arbitrary axes and rotation
ZrO₂
Case Study Validated
Crystal growth investigation of Zirconia identified preferential growth directions
Crystal Growth
Computational Insight
Systematic exploration of stability and preferential growth in NP geometries
Element Swap
Hypothetical Materials
In silico chemical substitutions to explore unsynthesized variant materials
Free
Web Access
Freely available on the Enalos Cloud Platform with no login required

Related Publication

Peer-Reviewed Paper

NanoConstruct: A web application builder of ellipsoidal nanoparticles for the investigation of their crystal growth, stability, and the calculation of atomistic descriptors

Kolokathis P.D., Zouraris D., Voyiatzis E., Sidiropoulos N.K., Tsoumanis A., Melagraki G., Tämm K., Lynch I., Afantitis A. — Computational and Structural Biotechnology Journal, 2024, 25:81–90 — DOI: 10.1016/j.csbj.2024.05.039